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Rest in Power Jim Simons
Manage episode 417914889 series 2491873
Indhold leveret af Autism Science Foundation. Alt podcastindhold inklusive episoder, grafik og podcastbeskrivelser uploades og leveres direkte af Autism Science Foundation eller deres podcastplatformspartner. Hvis du mener, at nogen bruger dit ophavsretligt beskyttede værk uden din tilladelse, kan du følge processen beskrevet her https://da.player.fm/legal.
A legend in the autism community passed away on Friday. Today’s podcast focuses on the many talents of Dr. James (Jim) Simons, one of the founders of the Simons Foundation that has spent more than $500 million on autism research. We explain how he made his fortune, how he spent it, the importance of the …
…
continue reading
127 episoder
Manage episode 417914889 series 2491873
Indhold leveret af Autism Science Foundation. Alt podcastindhold inklusive episoder, grafik og podcastbeskrivelser uploades og leveres direkte af Autism Science Foundation eller deres podcastplatformspartner. Hvis du mener, at nogen bruger dit ophavsretligt beskyttede værk uden din tilladelse, kan du følge processen beskrevet her https://da.player.fm/legal.
A legend in the autism community passed away on Friday. Today’s podcast focuses on the many talents of Dr. James (Jim) Simons, one of the founders of the Simons Foundation that has spent more than $500 million on autism research. We explain how he made his fortune, how he spent it, the importance of the …
…
continue reading
127 episoder
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×1 Do Transcranial Magnetic Stimulation and Direct Current Stimulation help people with autism? The latest science here. 12:17
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12:17Two therapies that are meant to alter brainwave activity, called Transcranial Magnetic Stimulation and Transcranial Direct Current Stimulation are receiving a lot of attention for potential efficacy in treating autism. They are non-invasive, which means treatment is provided on the scalp. While results vary, the overall evidence does not support these two interventions in helping to treat core autism features. However, as TMS is approved for depression and OCD, people should ask their doctors about these potential treatments if they suffer from these conditions. Learn more in the articles below: https://link.springer.com/article/10.1007/s00787-024-02635-z Click to access nihms-1934887.pdf https://academic.oup.com/cercor/article-abstract/34/13/8/7661139?redirectedFrom=fulltext&login=false…
1 We missed one for the 2024 year end summary: Proof of the importance of genetic testing in autism 27:41
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27:41It happens every year – this one belonged in the 2024 year end highlights but was published late in the year. Researchers at UCSD, UCLA and CHLA followed families with autism whose genetic test revealed a rare variant. Did it make a difference in care? Understanding? Referrals? If you are in need of a genetic test, here are some things to know: https://www.alliancegenda.org/genetic-testing Reference here: https://www.sciencedirect.com/science/article/pii/S1098360024002673…
1 The 2024 Autism Science Year in Review 13:10
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13:10New Technologies, New Data, New Solutions This year’s progress in autism research includes promising findings, clarifications, explanations, and the uncovering of new avenues of inquiry. The focus is now on personalized medicine: finding the right treatment for the right person at the right time through targeted interventions. Advances in technology and genetic testing are opening new avenues for therapeutics, rapid drug testing, and improved differentiation of subgroups of autism. 2024 Autism Science Review…
1 Online autism assessments as a perk of the pandemic 17:52
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17:52While it may not seem like it, the COVID-19 pandemic brought some advances in care and understanding for people on the spectrum. One example is the development and validity of remotely administered assessments that families can participate in from home rather than travel to a clinic. These tools were built out of necessity, and are evolving into a set of tools that can be used to build better outcome measures for clinical trials. This round focused on those with autism and a rare genetic variant or “neurogenetic syndromes” since these individuals have a known biological etiology of autism. However, they may be further improved to be utilized across the autism spectrum. https://pubmed.ncbi.nlm.nih.gov/39643599 https://pubmed.ncbi.nlm.nih.gov/39526825…
1 An update on why there are fewer autistic females compared to males 17:46
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17:46This week, special podcast correspondent #MiaKotikovski summarizes new research on the increasing prevalence of autism, with a focus on females. While the number of diagnosed females is increasing faster than the number for males, females assigned at birth still are less likely to receive a diagnosis than males. Additional evidence points to females having more genetic mutations and lower cognitive ability, so the questions remain: Are there females with autism who are just not getting diagnosed despite having all the autism features? Why not? Does autism in females “look” the same as autism in males? What sets them apart? These articles are all featured in the year-end highlight of research, so this is the time to get a deep explanation of the latest in sex differences in #autism. https://pubmed.ncbi.nlm.nih.gov/34563942 https://pubmed.ncbi.nlm.nih.gov/39334436 https://pubmed.ncbi.nlm.nih.gov/33966484…
1 Synaptic Density and Autism, explained 12:58
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12:58….or at a podcast with at least an attempt at an explanation of what synaptic density is and how it is affected in brains of people with autism. This week we review three convergent lines of evidence – whole brain, brain cell then genes within those brain cells – that show that the autistic brain has a decrease in cell-to-cell communication in multiple brain regions, leading to social communication impairments. https://www.science.org/doi/pdf/10.1126/science.adh2602?casa_token=bjtbuFi5U88AAAAA:_ffcE-pGCPxh4re24ix_xDgenAS1cAgDHLIMJJQCCG_1LvxaJKrGwEb9LFuMNsTYhvtGqRwro1A1Smc https://academic.oup.com/cercor/article-abstract/34/13/121/7661138?redirectedFrom=fulltext&login=false#no-access-message https://pubmed.ncbi.nlm.nih.gov/39367053…
1 Health Concerns Across 3 Generations 24:18
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24:18Are you the grandparent, cousin, aunt, uncle, sibling, or half-sibling of someone with autism and wondered “what is the likelihood of autism in families, and the likelihood of comorbid conditions if I have a family member with autism?” Researchers at the AJ Drexel Autism Research Institute and Aarhus University in Denmark collaborated to calculate probabilities between autism in a person and dozens of other comorbid conditions in family members. They not only made the paper open to the public for everyone to read it, but they also created a publicly available data visualization tool so anyone can go on and look at specific situations of particular family relationships relating to anything from autoimmune conditions to mental health and psychiatric diagnosis. Links below for reference: https://pubmed.ncbi.nlm.nih.gov/39283002 Interactive graphs: https://public.tableau.com/app/profile/diana.schendel/viz/ASDPlots_16918786403110/e-Figure5…
Despite many years fighting it, families with autism still experience societal stigma. The experiences depend on many factors, summarized in the October 21st podcast. This week, Mia Kotikovski explores cultural factors involved in stigma. As examples, she explores the literature from Asia, the Middle East and the United Kingdom, how they are different, and how families cope with that stigma in different areas of the world. https://link.springer.com/article/10.1007/s40489-023-00373-7 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330163 https://link.springer.com/article/10.1007/s10803-019-04218-3 https://www.nature.com/articles/s41598-022-23978-0 https://molecularautism.biomedcentral.com/articles/10.1186/s13229-023-00579-w https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0261774 https://onlinelibrary.wiley.com/doi/full/10.1002/aur.2652…
Animal models of autism, including cell based models, have received criticism because autism is a uniquely human condition so there is no value in studying it in a model like a mouse or a cell. On the other hand, model systems have been used for decades to develop therapies for a myraid of other conditions and disorders, and produced evidence-based treatments for not just autism but conditions from ADHD to schizophrenia. So why is there so much backlash about this line of research? The ASF podcast talks to Jill Silverman at UC Davis to get some perspective. https://pubmed.ncbi.nlm.nih.gov/35285132 https://www.vox.com/future-perfect/377739/autism-research-mice-lab-models…
1 Where is autism stigma the worst in the world? 17:02
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17:02This week, part 1 in cultural stigma around autism with Mia Kotikovski provides an overview of stigma, where it can come from across cultures and provides some examples of stigma in different countries. Different areas of the world are in different places in terms of their perceptions of autism, their needs for autism families, and what they perceive as their greatest difficulties. The topic is so important we broke it down into two sections. Please listen to both, it will explain a lot about autism services and supports around the world. https://journals.sagepub.com/doi/10.1177/1362361318823550 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8992913 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11303671 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11303671 https://pubmed.ncbi.nlm.nih.gov/30248583 https://pubmed.ncbi.nlm.nih.gov/38507392 https://www.researchgate.net/publication/277816405_A_Cross-Cultural_Comparison_of_Knowledge_and_Stigma_Associated_with_Autism_Spectrum_Disorder_Among_College_Students_in_Lebanon_and_the_United_States?enrichId=rgreq-97b7d5f50aac4d5b124ea8295b42fdb0-XXX&enrichSource=Y292ZXJQYWdlOzI3NzgxNjQwNTtBUzoyNDI4NTI2Mzk4NDIzMDRAMTQzNDkxMTk4OTI3MA%3D%3D&el=1_x_3&_esc=publicationCoverPdf…
1 Factors That Influence Heterogeity and How 34:00
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34:00Understanding factors that make each person with autism different has been a challenge, affecting diagnosis, interventions and the way we think about autism in general. Researchers at Istituto Italiano di Tecnologia, Rovereto, Italy, used computers to see how language, intellectual ability, motor and adaptive functioning grouped individuals into different categories. It turns out there are … Continue reading "Factors That Influence Heterogeity and How"…
A few years after the start of the pandemic, and a couple of years into “recovery”, scientists are still disentangeling the effects of COVID-19 lockdowns and exposure. For example, is there an uptick in autism screen positives when pregnant mothers fell ill? Were there diagnostic disparities based on co-morbid conditions? Did autistic people feel better … Continue reading "Post-Pandemic Problems"…
In part 2 of the GI series in ASD, a new paper in the Journal of Nutrition and Gastroenterology describing the www.candidgi.com meeting is described. While sometimes doctors may be know-it-alls, sometimes they do not know-it-all and need experts to advise them, especially when they encounter individuals who may be hard to diagnose and treat. … Continue reading "Catching up with CANDID"…
In the first of a two-part series on digestive health in ASD, Mia Kotikovski summarizes scientific information about what the complicated microbiome is, how it influences physical and psychiatric health, if it is altered in autism, and what causes it to be different in ASD.
1 More about the environmental influences in autism 15:38
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15:38New research points to a previously understudied but fascinating mechanism by which environmental factors may lead to autism: it’s called the “GABA/glutamate switch” which is a critical period in development when certain cells turn from turning on cell activity to turning them off. These environmental factors may delay this process leading to long term effects … Continue reading "More about the environmental influences in autism"…
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