A myriad of AI, science, and technology experts explore the real challenges and enormous opportunities facing entrepreneurs who are building the future of health. Raising Health, a podcast by a16z Bio + Health and hosted by Kris Tatiossian and Olivia Webb, dives deep into the heart of biotechnology and healthcare innovation. Join veteran company builders, operators, and investors Vijay Pande, Julie Yoo, Vineeta Agarwala, and Jorge Conde, along with distinguished guests like Mark Cuban, Greg ...
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Indhold leveret af Ryan Feldman and Ryan Feldman PharmD DABAT. Alt podcastindhold inklusive episoder, grafik og podcastbeskrivelser uploades og leveres direkte af Ryan Feldman and Ryan Feldman PharmD DABAT eller deres podcastplatformspartner. Hvis du mener, at nogen bruger dit ophavsretligt beskyttede værk uden din tilladelse, kan du følge processen beskrevet her https://da.player.fm/legal.
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Mini Episode: Who Seizes in Bupropion Overdose with Dr Ari Filip MD
MP3•Episode hjem
Manage episode 355440524 series 3382933
Indhold leveret af Ryan Feldman and Ryan Feldman PharmD DABAT. Alt podcastindhold inklusive episoder, grafik og podcastbeskrivelser uploades og leveres direkte af Ryan Feldman and Ryan Feldman PharmD DABAT eller deres podcastplatformspartner. Hvis du mener, at nogen bruger dit ophavsretligt beskyttede værk uden din tilladelse, kan du følge processen beskrevet her https://da.player.fm/legal.
- TL;DR
- Your patient can seize 8-24 hours in, usually they have neurologic symptoms and tachycardia before hand
- Tachycardia may be masked by coingestions and symptoms may be very delayed
- Do not discharge a patient without discussing observation time with a toxicologist or poison center
- Do not dismiss tachycardia and anxiety as situational in a bupropion overdose
- Spiller 1994- Review of instant release product overdoses
- Shepherd 2004- Seizures in primarily sustained release products
- Most seizures had prodromal neuropsychiatric symptoms
- Starr 2009- Seizure in XL products.
- Tachycardia, tremor, agitation most associated with seizures
- Seizure occured as late as 24 hours and 25% occurred after 8 hours
- Offerman 2020- Primarily sustained/extended release products
- Tachycardia duration, and extent (>120) predicted seizure. (Hypotnesion and neuropsych symptoms also predict)
- Late seizure occurred only in those with symptoms on presentation
- Those who had cardiac arrest had prehospital seizure= bad sign
- Rianprakaisang 2021- ToxIC review of risk factors for seizures
- QTc and HR>140 predict seizures
56 episoder
MP3•Episode hjem
Manage episode 355440524 series 3382933
Indhold leveret af Ryan Feldman and Ryan Feldman PharmD DABAT. Alt podcastindhold inklusive episoder, grafik og podcastbeskrivelser uploades og leveres direkte af Ryan Feldman and Ryan Feldman PharmD DABAT eller deres podcastplatformspartner. Hvis du mener, at nogen bruger dit ophavsretligt beskyttede værk uden din tilladelse, kan du følge processen beskrevet her https://da.player.fm/legal.
- TL;DR
- Your patient can seize 8-24 hours in, usually they have neurologic symptoms and tachycardia before hand
- Tachycardia may be masked by coingestions and symptoms may be very delayed
- Do not discharge a patient without discussing observation time with a toxicologist or poison center
- Do not dismiss tachycardia and anxiety as situational in a bupropion overdose
- Spiller 1994- Review of instant release product overdoses
- Shepherd 2004- Seizures in primarily sustained release products
- Most seizures had prodromal neuropsychiatric symptoms
- Starr 2009- Seizure in XL products.
- Tachycardia, tremor, agitation most associated with seizures
- Seizure occured as late as 24 hours and 25% occurred after 8 hours
- Offerman 2020- Primarily sustained/extended release products
- Tachycardia duration, and extent (>120) predicted seizure. (Hypotnesion and neuropsych symptoms also predict)
- Late seizure occurred only in those with symptoms on presentation
- Those who had cardiac arrest had prehospital seizure= bad sign
- Rianprakaisang 2021- ToxIC review of risk factors for seizures
- QTc and HR>140 predict seizures
56 episoder
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