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The Discovery of Non-Steroidal Anti-inflammatory Drugs (NSAIDs), Part 1
Manage episode 418547704 series 3560282
Indhold leveret af Healio, Adam J. Brown, and MD. Alt podcastindhold inklusive episoder, grafik og podcastbeskrivelser uploades og leveres direkte af Healio, Adam J. Brown, and MD eller deres podcastplatformspartner. Hvis du mener, at nogen bruger dit ophavsretligt beskyttede værk uden din tilladelse, kan du følge processen beskrevet her https://da.player.fm/legal.
Humans have had an insatiable appetite for inhibiting production of prostaglandins for centuries! This series delves into the history of aspirin and NSAIDs, looking at the understanding of the prostaglandin pathway.
· Intro 0:12
· In this episode 0:23
· What are NSAIDs? 0:53
· Prostaglandins 5:50
· What are prostaglandins? 7:19
· Where do prostaglandins come from? 8:45
· So, what do we do with prostaglandins? 13:15
· How did they figure out prostaglandins? 13:55
· Naming the prostaglandin 21:25
· Phospholipids 24:46
· Arachidonic acid 25:28
· Arachidonic acid into prostaglandins: how do you prove it? 26:32
· How does arachidonic acid turn into prostaglandins? 27:27
· Cyclo-oxygenase 28:36
· mRNA and COX-2 32:50
· On the next episode 35:55
· Summary 36:38
· Thanks for listening 37:49
Disclosures: Brown reports no relevant financial disclosures.
We’d love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum.
References:
Botting RM. Pharmacol Rep. 2010;doi:10.1016/s1734-1140(10)70308-x.
Flower RJ. Br J Pharmacol. 2006;doi:10.1038/sj.bjp.0706506.
Flower RJ. Br J Pharmacol. 2019;doi:10.1111/bph.14588.
Kurzrok R, et al. Exp Biol Med. 1930;doi:10.3181/00379727-28-5265.
https://www.nobelprize.org/prizes/medicine/1970/euler/biographical/.
von Euler US. J Physiol. 1936;doi:10.1113/jphysiol.1936.sp003433.
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