Live at Annual Episode 3: Clinical Trials - Early Drain with Dr Stefan Wolf

Neurocritical Care Society Podcast

Aneurysmal subarachnoid hemorrhage (SAH) may be complicated by delayed cerebral ischemia, which is a major cause of unfavorable clinical outcome and death in SAH-patients. Delayed cerebral ischemia is presumably related to the development of vasospasm triggered by the presence of blood in the basal cisterns. To date, oral application of the calcium antagonist nimodipine is the only prophylactic treatment for vasospasm recognized under international guidelines.In retrospective trials lumbar drainage of cerebrospinal fluid has been shown to be a safe and feasible measure to remove the blood from the basal cisterns and decrease the incidence of delayed cerebral ischemia and vasospasm in the respective study populations. However, the efficacy of lumbar drainage had not been evaluated prospectively in a randomized controlled trial until Dr Stefan Wolf and his colleagues at Charité – Universitätsmedizin in Berlin conducted their study. Dr Wolf joins Dr Nick Morris to discuss the study's results.

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