Bedste Spectives-podcasts (2024)

1
What 3 Big Trials Mean for Breast Cancer Practice 12:48

2d ago12:48

12:48

Treatment approaches for patients with hormone receptor (HR)-positive, HER2-negative breast cancer have rapidly evolved, thanks in part to data from three key studies. Erin Frances Cobain, MD, associate professor at the University of Michigan Rogel Cancer Center in Ann Arbor, explains how findings from the KEYNOTE-756, monarchE, and NATALEE clinica…

1
137: Deadly Premonition (with Patrick & James - Retro Spectives) 2:48:26

21d ago2:48:26

2:48:26

There has been a lot of talk about the cult classic "7/10 game" lately, and no game better exemplifies this than Deadly Premonition (Access Games, 2010). It's one of those games where the average might land on 7/10 because there will be a lot of 10's and a lot of 3's in the review score distribution. Memorable characters, poor graphics, lifelike to…

1
140: Decarnation (with Jala Prendes - Jala-chan's Place, The Level & Dave Cox - Monster Dear Monster) 2:44:59

11h ago2:44:59

2:44:59

Have you ever thought to yourself, "how scary could this pixel art horror game be? It's just pixels!". If so, you and I are the same. And granted, Decarnation (Atelier QDB, 2023) isn't an in-your-face type of horror. It's more of a psychological, empathetic horror and dread for what your character is going through. And it's very, very effective! Th…

1
139: Devotion (with Jill Grodt - The Indie Informer) 1:56:43

7d ago1:56:43

1:56:43

Stop me if you've heard this story before. A game that I once thought would be too scary for me to play, so I spoiled the entire story for myself only to realize that it sounded too good to not experience for myself. Add Devotion (Red Candle Games, 2019) to that list. Despite the controversy surrounding the game and subsequent delisting from all ma…

1
“Confusing for All of Us”: Questions Arise Over ADCs, HER2 in Metastatic Breast Cancer 14:02

9d ago14:02

14:02

Approvals of antibody-drug conjugates (ADCs) for metastatic breast cancer have introduced complex questions about HER2 expression. “It’s certainly been a changing landscape, which has been confusing for all of us,” explains Ian Krop, MD, PhD, director of the clinical trials office, chief clinical research officer, and associate director for clinica…

1
138: Silent Hill (with Stephanie Klimov - Boss Rush Network) 1:50:19

14d ago1:50:19

1:50:19

As a fan of Silent Hill 2 (episode 10 of Tales from the Backlog, by the way), I figured at some point I would need to go back and play the original. Silent Hill (Team Silent, Konami, 1999) was really interesting to go back and play, for a couple of reasons, most notably that I thought I knew what the game and town's whole deal was, but that was app…

1
136: Omori (with Aaron Angle - A Top 3 Podcast) 2:23:43

28d ago2:23:43

2:23:43

Sometimes a game has such striking and memorable art that one screenshot will implant that game into your head, even if you never play it. Omori (Omocat, 2020) was almost one of those games for me. A combination of thinking the game would be too scary and having tons of other games available kept Omori on the periphery for a long time, until today'…

1
"Where Do We Go From Here?" Targeted Therapies Lead to Challenging Choices in Breast Cancer 11:00

1M ago11:00

11:00

Newly approved targeted therapies for patients with advanced hormone receptor (HR)-positive, HER2-negative breast cancer are changing care. “We have an abundance of opportunities, but challenges with having to choose the right opportunity at the right time,” says Robert A. Figlin, MD, the Steven Spielberg Family Chair in Hematology-Oncology at the …

1
135: Lost Odyssey (with Ryan Batie - Lightning Strikes Thrice) 2:53:26

1M ago2:53:26

2:53:26

Lost Odyssey, by Mistwalker and feelplus, is almost legendary at this point. A darker, sadder RPG by Final Fantasy series creator Hironobu Sakaguchi, with a moody yet eclectic soundtrack by Final Fantasy series composer Nobuo Uematsu and short stories interspersed throughout by famed Japanese author Kiyoshi Shigematsu, there is pedigree and talent …

1
134: A Space for the Unbound (with CGDannyB) 2:03:51

1M ago2:03:51

2:03:51

Friends of the show probably know that I love games (especially indie games) set in "uncommon" real world settings- those outside of the US, Japan and Western Europe. Mojiken Studio's 2023 title A Space for the Unbound is one of those, set in Indonesia. That was the draw for me- an emotional story set in a place that I've been in real life. I didn'…

1
S2 Ep16: Patient, Provider, & Caregiver Connection: Individualizing Care in Hemophilia A to Optimize Joint Health and Prevent Synovitis 40:44

2M ago40:44

40:44

Af PER® Spectives

1
133: Final Fantasy IV (with Chris Coplien - Retro Hangover & Jenny E.) 2:25:37

2M ago2:25:37

2:25:37

Final Fantasy is one of the most well-represented series on this podcast, and its anthology structure means you can pick and choose which games you want to play without fear of playing out of order. So this year, I wanted to make sure I played a foundational one- Final Fantasy IV. I expected this to be the turning point where Square and the Final F…

1
E124: Crysis 1:15:50

2M ago1:15:50

1:15:50

But can it run Crysis? This was the motto that surrounded every single PC build for literal years after the release of the game in 2007. Crytek were not satisfied with what they had achieved with Far Cry in 2004, and decided to push graphical hardware to its absolute limits with their brand new and shiny game. And boy, did they succeed, with a poor…

1
132: Pony Island (with Chris - 1H1D) 1:25:33

2M ago1:25:33

1:25:33

Do you ever feel like you missed the boat on a game? Maybe it was really influential and subsequent games used its "trick"? Maybe you wonder if that OG still has the juice even though you couldn't possibly go into the game completely blind? These were the thoughts running through my mind as I booted up Pony Island by Daniel Mullins Games for the fi…

1
After Practice Change in Unresectable Stage III NSCLC, Questions Remain 10:30

2M ago10:30

10:30

Data on the use of durvalumab after chemoradiotherapy transformed the standard of care for patients with unresectable stage III non-small cell lung cancer (NSCLC). “This is a real practice-changing observation from the PACIFIC trial,” said Robert A. Figlin, MD, the Steven Spielberg Family Chair in Hematology-Oncology at the Cedars-Sinai Cancer Cent…

1
What "Incredibly Dramatic" Data on Osimertinib in NSCLC Mean for Practice 9:47

2M ago9:47

9:47

Results of the phase 3 LAURA clinical trial, presented at the 2024 American Society of Clinical Oncology Annual Meeting, showed that osimertinib significantly improves progression-free survival in patients with unresectable stage III EGFR-mutant non-small cell lung cancer (NSCLC) after chemoradiotherapy. “The benefits of osimertinib in this patient…

1
131: Animal Well (with Jenny Windom - Geeks & Grounds) 2:09:34

2M ago2:09:34

2:09:34

Animal Well, by Billy Basso/Shared Memory came out of nowhere. For me, and I think a lot of others, the initial announcement was more of a shock that videogamedunkey had started the BigMode publishing company than excitement about the game being published. Once people got their hands on Animal Well, however, all skepticism or publicity about dunkey…

1
“Smart Bombs” Upend Breast Cancer Care: What Oncologists May Not Know About Antibody-Drug Conjugates 10:08

2M ago10:08

10:08

“I think the antibody-drug conjugates (ADCs) for physicians, and certainly patients too, are a little bit tough to wrap your head around,” says Erika P. Hamilton, MD, the director of breast cancer and gynecologic cancer research at Sarah Cannon Research Institute in Nashville. She discusses how TROP2-targeting ADCs currently fit into practice with …

1
130: Dave the Diver (with Dave Cox - Monster Dear Monster) 2:10:15

2M ago2:10:15

2:10:15

Dave the Diver, despite clearly having a great character name, is not my kind of game. Mintrocket's dive-collect-sell-upgrade-dive loop is one that I'm not very motivated by, but Dave the Diver got such unanimous acclaim that I had to take note. And apparently the patrons of the show wanted me to play it as well, because it won one of the montly po…

1
129: Pizza Tower (with Aaron Klaassen - Super Pod Saga) 57:21

3M ago57:21

57:21

Since Nintendo has apparently decided that Wario Land is a series not worth pursuing, we find ourselves telling that familiar story where an indie developer says "ok, they're not making the game I want to play any more....guess it's up to me!". Enter developer Tour De Pizza and their love letter to Wario Land, Sonic the Hedgehog and all manner of 1…

1
Oncology Must Do More for Long-Term Cancer Survivors, Expert Says 11:27

3M ago11:27

11:27

Various survivorship guidelines for pediatric patients have been established, but “such guidelines do not exist in the adult world,” says Smita Bhatia, MD, MPH, director of the Institute for Cancer Outcomes and Survivorship and the Gay and Bew White Endowed Professor in Pediatric Oncology at the University of Alabama at Birmingham. With the number …

1
128: Like a Dragon: Infinite Wealth (with Deadbeatpunk - WTFDYW!?) 2:23:40

3M ago2:23:40

2:23:40

I am FINALLY caught up with Ryu Ga Gotoku and Sega's Yakuza/Like a Dragon franchise, and let me tell you, it feels great to play the games as they release now. This time, in Like a Dragon: Infinite Wealth, Ichiban, Kiryu and friends take on the streets of Honolulu. This episode talks about the new story, the unique logistical challenge that the non…

1
“A Good, Peaceful Death” From Cancer: Oncologists Must Be Part of “National Dialogue” 12:00

3M ago12:00

12:00

Obstacles to “achieving a good, peaceful death” prevent many patients with cancer from the “dignified end” that they deserve, says Sunita Puri, MD, a palliative care physician and author. She and Robert A. Figlin, MD, the Steven Spielberg Family Chair in Hematology-Oncology at the Cedars-Sinai Cancer Center in Los Angeles, discuss frustrations and …

1
127: Metal Gear Solid 3: Snake Eater (with Katie Lesperance - Left Behind Game Club) 2:28:15

3M ago2:28:15

2:28:15

Continuing along my journey of playing Konami and Hideo Kojima's Metal Gear Solid series, next up is Metal Gear Solid 3: Snake Eater. This is the one that is most often held up as the greatest in the series, and I can absolutely see why. It's not without flaws- it's still clunky to play and continues the trend of no Metal Gear Solid game having nor…

1
E123: Resident Evil 2 1:08:35

3M ago1:08:35

1:08:35

After their magnum opus that was Resident Evil 1, Capcom were not going to sit on their heels. Coming out just two years after the first in 1998, Resident Evil 2 sought to have everything the original had and much, much more. It connected its two character’s stories in far more meaningful ways, increased the size of each player's inventory (and the…

1
FDA Approvals in Relapsed/Refractory CLL Set up "Difficult Choice" 9:59

3M ago9:59

9:59

When it comes to the treatment of patients with relapsed/refractory chronic lymphocytic leukemia (CLL), "within the last eight months or so, we have had some exciting new events," says Daniel A. Ermann, MD, a hematologist-oncologist and assistant professor at the University of Utah Huntsman Cancer Institute in Salt Lake City. The U.S. Food and Drug…

1
Oncologists Struggling With Cancer Deaths Among Millennial Patients 11:36

3M ago11:36

11:36

Oncologists are struggling with the rising cancer mortality rate among millennial patients. "I think treating people our own age is definitely a trigger for a lot of people," said Sunita Puri, MD, a palliative-care physician and author. She spoke with Robert A. Figlin, MD, the Steven Spielberg Family Chair in Hematology-Oncology at the Cedars-Sinai…

1
126: Cocoon (with Brenden Groom - Pass the Controller) 1:15:32

3M ago1:15:32

1:15:32

Every now and then, I want to take a break from story-focused games and just play a puzzle-ass puzzle game. Geometric Interactive's Cocoon was just what the doctor ordered, from that perspective. But Cocoon's world hinted at a deeper story, one that seems inaccessible yet present, and that left me with a feeling of want, despite how great the puzzl…

1
Elden Ring: Shadow of the Erdtree (Preview) (with Charlie Young) 1:09:57

3M ago1:09:57

1:09:57

In this bonus episode, I'm joined by returning guest Charlie Young to discuss FromSoftware's Elden Ring: Shadow of the Erdtree expansion. The public feed includes roughly the first half of the episode, and all paid members at [patreon.com/realdavejackson](patreon.com/realdavejackson) will get the entire discussion. This is a full spoiler discussion…

1
125: Gris (with Eric Gess - The Unlockables) 2:04:43

4M ago2:04:43

2:04:43

I was convinced to try out Gris after seeing a single screenshot, but in true gamer fashion, I bought it a few years before finally playing it. It took the backlog resolutions challenge in our Discord server to finally get me to play it, and unsurprisingly, I was hooked by what Nomada Studio had created immediately. The marriage of art, music, game…

1
124: Lisa: The Painful (with Rick Firestone - Pixel Project Radio) 2:42:50

4M ago2:42:50

2:42:50

For any lover of RPGs, and especially "weird RPGs", as former guest on the show Rebekah Valentine termed them, Lisa: The Painful, by Dingaling Productions, will probably jump out at you. From its art style, non-pretty boy protagonist to its serious themes and punishing gameplay, this is not a game for the faint of heart. However, if you are willing…

1
Top Lung Cancer Data From ASCO 2024 Should Change Practice “Immediately,” Experts Agree 12:23

4M ago12:23

12:23

Thoracic oncology was a major focus of the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting, says Sandip P. Patel, MD, a medical oncologist and professor of medicine at the University of California San Diego. Practice-changing data were presented in both non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC), Dr. Patel…

1
E122: The Legend of Zelda 1:09:44

4M ago1:09:44

1:09:44

The Legend of Zelda is perhaps the most iconic video game series of all time. Boasting 19 mainline entries, and an endless swathe of critical acclaim and awards, it's hard to find someone who hasn’t at least heard of the action/adventure story of Link and Zelda. It all began back in 1986 with the release of the first game for the Famicom in Japan. …

1
What Were the Biggest Data at ASCO 2024 in Kidney Cancer? 11:41

4M ago11:41

11:41

The biggest data at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting in kidney cancer focused on biomarkers, says Brian I. Rini, MD, chief of clinical trials and the Ingram Professor of Cancer Research at the Vanderbilt-Ingram Cancer Center in Nashville. He discussed data from KEYNOTE-426 and several other key trials with Robert…

1
What New “Elephant in the Room” Means for Bladder Cancer Care 14:00

4M ago14:00

14:00

Enfortumab vedotin plus pembrolizumab (EV/pembro) has “become the elephant in the room” when it comes to bladder cancer care, says Jonathan E. Rosenberg, MD, chief of genitourinary oncology service at Memorial Sloan Kettering Cancer Center in New York City. At the 2024 American Society of Clinical Oncology Annual Meeting, he discussed recent key ad…

1
123: 1000xRESIST (with Michael Higham) 1:55:05

4M ago1:55:05

1:55:05

Sunset Visitor's 1000xRESIST came out of nowhere for me. Releasing on May 9th, 2024 meant it faced stiff indie competition on its day of release, and it wasn't until others were shouting from the rooftops that I found myself drawn to try it out (and a big thank you to Sunset Visitor and Fellow Traveler for the review code!). What I found was a stor…

1
Immunotherapy in “Hardest Stage” of NSCLC: Putting Recent Advances Into Practice 12:08

4M ago12:08

12:08

Immunotherapy in “Hardest Stage” of NSCLC: Putting Recent Advances Into Practice Our host, Robert A. Figlin, MD, FACP, welcomes Melissa L. Johnson, MD, as a guest

1
"We're Past the Inflection Point," as "Massive Change" Hits Breast Cancer Care 13:54

4M ago13:54

13:54

From ASCO 2024. When it comes to the use of antibody-drug conjugates (ADCs) in breast cancer care, "we're past the inflection point," says Hope S. Rugo, MD, a breast cancer oncologist and professor of medicine in the Division of Hematology and Oncology at the University of California San Francisco Helen Diller Family Comprehensive Cancer Center.…

1
To Get Better Cancer Drugs Faster, Is It Time for an “International FDA"? 13:06

4M ago13:06

13:06

From ASCO 2024 The time it takes for a novel cancer therapy to go from investigational new drug application to U.S. Food and Drug Administration (FDA) approval is typically longer than a decade. “There has to be a better way,” says Bob T. Li, MD, PhD, MPH, a medical oncologist at Memorial Sloan Kettering Cancer Center in New York City and associate…

1
122: Mother 3 (with Rebekah Valentine) 2:41:16

4M ago2:41:16

2:41:16

Famously never localized for an English-speaking audience, HAL Laboratory and Brownie Brown's Mother 3 has almost become a meme at this point. So much so that I wondered if it could live up the inflated expectations that I unwittingly put on games that are unavailable or difficult to find, a kind of forbidden fruit syndrome. So I made sure to put M…

1
E121: Killer 7 2:20:23

4M ago2:20:23

2:20:23

Killer7 is one weird game. Developed in tandem by Grasshopper Manufacture and Capcom and first released in 2005, its very existence as a game defies description. Within moments of starting, you’re placed into a world with talking bondage ghosts, a TV channel that drains your blood, and abstract puzzles that would fit right into Resident Evil. Combi…

1
"Very Important" Myeloma Data: ASCO Highlights, Smoldering Challenges, and More 12:32

4M ago12:32

12:32

From ASCO 2024, Dr. Robert Figlin speaks with Dr. Samer Al Hadadi from University of Arkansas. "Very Important" Myeloma Data: ASCO Highlights, Smoldering Challenges, and More.

1
121: The Last Guardian (with Chris - Franchise Festival) 2:11:48

4M ago2:11:48

2:11:48

Fumito Ueda's trilogy of Playstation games- Ico, Shadow of the Colossus and The Last Guardian- are idiosyncratic, minimalist art pieces. The final game in the trilogy, before the unfortunate dissolution of Japan Studio, was The Last Guardian, showcasing the uneasy partnership between an unnamed boy and a large, fearsome beast named Trico. The Last …

1
Durvalumab's Benefit in SCLC "Beyond What We Might Have Expected" 10:29

4M ago10:29

10:29

From ASCO 2024, Dr. Robert Figlin talks with Dr. Lauren Averett Byers from MD Anderson Cancer Center. Durvalumab's Benefit in SCLC "Beyond What We Might Have Expected"

1
New Standard of Care in Melanoma? Neoadjuvant Immunotherapy Offers "Fantastic" Potential, Expert Says 25:13

5M ago25:13

25:13

From ASCO 2024 New Standard of Care in Melanoma? Neoadjuvant Immunotherapy Offers "Fantastic" Potential, Expert Says. Dr. Robert Figlin speaks with Dr. Christian Blank from Leiden University

1
120: Roadwarden (with Bryan Skursha - Pixelated Playgrounds) 2:14:31

5M ago2:14:31

2:14:31

From the first screenshot I saw of Roadwarden (Moral Anxiety Studio), I knew that I needed to check the game out. The art is simple, yet striking, and any screenshot will convey the quality of writing. Once I booted up the game, I found that the choose-your-adventure writing, the confident RPG mechanics and the music wrapped this into a rich total …

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