Bedste Metastasis-podcasts (2024)

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Latín América-Episodio #35. Dr. Roberto Hernandez Alejandro. Transplante of Colorectal Liver Metastasis. 1:24:15

23d ago1:24:15

1:24:15

El Dr. Roberto Hernandez-Alejandro ha sido Jefe de la División de Trasplantes en la Universidad de Rochester desde agosto de 2016. Bajo su liderazgo, expandió las oportunidades de trasplante mediante el aumento del uso de órganos donados después de la muerte cardíaca. Recientemente, el Dr. Hernandez abrió un programa de trasplante hepático para met…

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Nanobody Inhibits Metastasis of Breast Tumor Cells to Lung in Mice 2:53

26d ago2:53

2:53

BUFFALO, NY- August 15, 2024 – A new #research paper was #published in Oncotarget's Volume 15 on August 14, 2024, entitled, “A nanobody against the V-ATPase c subunit inhibits metastasis of 4T1-12B breast tumor cells to lung in mice.”The vacuolar H+-ATPase (V-ATPase) is an ATP-dependent proton pump that functions to control the pH of intracellular …

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Key Roles of MIF, DDT, and CD74 in Melanoma Prognosis and Therapy 4:02

13d ago4:02

4:02

Macrophage Migration Inhibitory Factor (MIF) and its homolog D-dopachrome Tautomerase (DDT) have been implicated as drivers of tumor progression in various cancers. Recent evidence suggests that MIF could be a therapeutic target in immune checkpoint inhibition (ICI) resistant melanomas; however, clinical evidence for MIF, and particularly for DDT, …

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miR-10b Inhibition: A Strategy for Treating Metastatic Breast Cancer 2:41

13d ago2:41

2:41

BUFFALO, NY- August 28, 2024 – A new #research paper was #published in Oncotarget's Volume 15 on August 26, 2024, entitled, “Inhibition of miR-10b treats metastatic breast cancer by targeting stem cell-like properties.”As stated within the Abstract of the paper, despite advances in breast cancer screening and treatment, the prognosis for metastatic…

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Artificial Intelligence: Revolutionizing Precision Oncology 2:21

14d ago2:21

2:21

BUFFALO, NY- August 27, 2024 – A new #editorial was #published in Oncotarget's Volume 15 on August 26, 2024, entitled, “Artificial intelligence: A transformative tool in precision oncology.”Artificial intelligence (AI) is revolutionizing society and healthcare, opening new possibilities for precision medicine. In oncology, immunotherapy (IO) has si…

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ECG Overtime: Episode 6 - The New HPB Surgeon, Beyond Surgery 51:58

14d ago51:58

51:58

Join us for another episode of our series ECG Overtime, hosted by the E-AHPBA/IHPBA Early Career Group! This episode features Dr. Sanket Srinivasa, Dr. Tay Wee Ming, and Dr. Saneya Pandrowala. Enjoy an episode in which we continue the conversation started during the Asia/Pacific Webinar about life beyond surgery as a new HPB surgeon!…

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Genotype Matters: Tailored Screening for Germline CHEK2 Variants 2:45

15d ago2:45

2:45

BUFFALO, NY- August 26, 2024 – A new #editorial was #published in Oncotarget's Volume 15 on July 10, 2024, entitled, “Genotype matters: Personalized screening recommendations for germline CHEK2 variants.”Recognized as a moderate-risk gene, CHEK2—responsible for encoding the CHK2 protein, which plays a crucial role in the repair of DNA double-strand…

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Disrupting NKG2A:HLA-E Interactions for Enhanced Anti-Cancer Immunity 2:39

20d ago2:39

2:39

BUFFALO, NY- August 21, 2024 – A new #editorial was #published in Oncotarget's Volume 15 on July 17, 2024, entitled, “Strategies to disrupt NKG2A:HLA-E interactions for improved anti-cancer immunity.”Two studies using CRISPR screens in cancer cells identified HLA-E as a critical negative regulator of NK cell interactions with cancer cells. Consiste…

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Role of the Gut Barrier in Colorectal Cancer Treatment 2:42

22d ago2:42

2:42

BUFFALO, NY- August 19, 2024 – A new #review was #published in Oncotarget's Volume 15 on August 14, 2024, entitled, “The gut barrier as a gatekeeper in colorectal cancer treatment.”Colorectal cancer (CRC) is highly prevalent and a major cause of cancer-related deaths worldwide. The primary curative treatment for CRC is surgical resection of the aff…

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Response of BRAF-Mutated Spindle Cell Sarcoma to BRAF/MEK Inhibitors 2:48

27d ago2:48

2:48

BUFFALO, NY- August 14, 2024 – A new #casereport was #published in Oncotarget's Volume 15 on July 17, 2024, entitled, “Rapid but nondurable response of a BRAF exon 15 double-mutated spindle cell sarcoma to a combination of BRAF and MEK inhibitors.”As noted in the introduction of the Abstract, the BRAF V600E substitution predicts a cancer's sensitiv…

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New Directions in Targeting the Multifaceted BRAF in Cancer 2:28

29d ago2:28

2:28

BUFFALO, NY- August 12, 2024 – A new research perspective was published in Oncotarget's Volume 15 on July 16, 2024, entitled, “Targeting the multifaceted BRAF in cancer: New directions.”In cancer patients, BRAF-targeting precision therapeutics are effective against Class I BRAF alterations (p.V600 hotspot mutations) in tumors such as melanoma, thyr…

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Combining Regorafenib and TAS102 to Target Gastrointestinal Cancers and Overcome Cancer Stemness 4:01

1M ago4:01

4:01

In this research paper, researchers demonstrate a promising new treatment option for refractory metastatic gastrointestinal cancers using a combination of two FDA-approved drugs.Researchers Jun Zhang, Lanlan Zhou, Shuai Zhao, and Wafik S. El-Deiry from Fox Chase Cancer Center and Brown University explore the potential of combining TAS102 (triflurid…

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TCR CDR3s and Renalase-1 Linked to Increased Melanoma Survival 2:31

1M ago2:31

2:31

BUFFALO, NY- August 8, 2024 – A new #research paper was #published in Oncotarget's Volume 15 on August 5, 2024, entitled, “Chemical complementarity of tumor resident, T-cell receptor CDR3s and renalase-1 correlates with increased melanoma survival.”As mentioned in the Abstract of this study, overexpression of the secretory protein renalase-1 negati…

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Dealing with Runaway Metastatic Disease 1:59

1M ago1:59

1:59

BUFFALO, NY - August 7, 2024 – A new #editorial paper was #published in Oncotarget's Volume 15 on July 12, 2024, entitled, “How to deal with runaway metastatic disease?”In this new editorial, Justine Paris and Guilhem Bousquet from Université Paris Cité, Université Sorbonne Paris Nord, and APHP, Hôpital Avicenne, Oncologie médical, discussed how th…

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INT-1B3 miR-193a-3p Mimic Boosts T Cell Immunity and Induces Tumor Cell Death 2:34

1M ago2:34

2:34

BUFFALO, NY- August 5, 2024 – A new #research paper was #published in Oncotarget's Volume 15 on July 12, 2024, entitled, “INT-1B3, an LNP formulated miR-193a-3p mimic, promotes anti-tumor immunity by enhancing T cell mediated immune responses via modulation of the tumor microenvironment and induction of immunogenic cell death.”In this study, resear…

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ECG Overtime: Episode 5 - Live from Cape Town - International Collaborations: The GECKO Model 23:37

1M ago23:37

23:37

The early career group of IHPBA presents recording from discussions at the Early Career Retreat and ECG Lounge sessions from the 2024 IHPBA World Congress in Cape Town. In this episode, Drs. Ewen Harrison and Deirdre Kruger review opportunities and lessons learned from international collaborations in global surgical research, using the example of t…

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ECG Overtime: Episode 4 - Live from Cape Town - Taking Part in the Editorial Process 21:53

1M ago21:53

21:53

The early career group of IHPBA presents recording from discussions at the Early Career Retreat and ECG Lounge sessions from the 2024 IHPBA World Congress in Cape Town. In this episode, we discuss challenges and controversies in the editorial process, with a focus on the involvement of trainees and early career surgeons, with Drs. Giovanni Marchegi…

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Prognostic and Therapeutic Insights Into MIF, DDT, and CD74 in Melanoma 3:32

2M ago3:32

3:32

BUFFALO, NY- July 26, 2024 – A new #research paper was #published in Oncotarget's Volume 15 on July 19, 2024, entitled, “Prognostic and therapeutic insights into MIF, DDT, and CD74 in melanoma.”Macrophage Migration Inhibitory Factor (MIF) and its homolog D-dopachrome Tautomerase (DDT) have been implicated as drivers of tumor progression across a va…

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Novel Triple-Drug Combination to Fight Pancreatic Cancer 8:10

2M ago8:10

8:10

In the ever-evolving quest for effective cancer treatments, researchers are continuously exploring innovative combinatorial approaches that exploit the vulnerabilities of malignant cells. In a new study, researchers Benigno C. Valdez, Apostolia M. Tsimberidou, Bin Yuan, Yago Nieto, Mehmet A. Baysal, Abhijit Chakraborty, Clark R. Andersen, and Borje…

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Prevalence and Impact of the KIT M541L Variant in Patients with Mastocytosis 2:54

2M ago2:54

2:54

BUFFALO, NY- July 24, 2024 – A new #research paper was #published in Oncotarget's Volume 15 on July 22, 2024, entitled, “Prevalence and impact of the KIT M541L variant in patients with mastocytosis.”Activating mutations in KIT, particularly D816V, have been associated with mastocytosis. Additionally, expression of heterozygous KIT M541L has been pr…

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Oncotarget Welcomes New Editorial Board Members 1:40

2M ago1:40

1:40

BUFFALO, NY - July 22, 2024 – Oncotarget proudly welcomes new members to our esteemed Editorial Board, including our new Co-Editor-in-Chief, Dr. Wafik S. El-Deiry. Joining Dr. El-Deiry on Oncotarget’s Editorial Board are Dr. Trever Bivona, Dr. Phillip Buckhaults, Dr. Fred Bunz, Dr. Jonathan Chernoff, Dr. Stephen G. Chun, Dr. Nathan Dolloff, Dr. Pei…

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Efficacy of Pembrolizumab with sEphB4-HSA in HPV-negative EphrinB2-positive HNSCC 3:21

2M ago3:21

3:21

BUFFALO, NY- July 22, 2024 – A new #research paper was #published in Oncotarget's Volume 15 on July 10, 2024, entitled, “Improved efficacy of pembrolizumab combined with soluble EphB4-albumin in HPV-negative EphrinB2 positive head neck squamous cell carcinoma.”Patients with relapsed or metastatic head and neck squamous cell carcinoma (HNSCC) after …

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ECG Overtime: Episode 3 - Live from Cape Town - Getting Published: Tips from the Editor 23:49

2M ago23:49

23:49

The early career group of IHPBA presents a recording from discussions at the Early Career Retreat and ECG Lounge sessions from the 2024 IHPBA World Congress in Cape Town. In this episode, Dr. Stephen Wigmore, Editor-in-Chief of HPB, reviews tips to get a manuscript published, with moderators Drs. Timothy Newhook and Julia Menso.…

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DDX41’s Unique Contribution to Myeloid Leukemogenesis 2:35

2M ago2:35

2:35

BUFFALO, NY- July 19, 2024 – A new #editorial paper was #published in Oncotarget's Volume 15 on July 2, 2024, entitled, “DDX41 and its unique contribution to myeloid leukemogenesis.”In this new editorial, researcher Hirotaka Matsui from the National Cancer Center Hospital in Tokyo, Japan, and Kumamoto University discusses myeloid neoplasms. Until t…

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Using Early On-treatment ctDNA Measurements as Response Assessment in mCRPC 2:34

2M ago2:34

2:34

BUFFALO, NY- July 17, 2024 – A new #editorial paper was #published in Oncotarget's Volume 15 on July 2, 2024, entitled, “Using early on-treatment circulating tumor DNA measurements as response assessment in metastatic castration resistant prostate cancer.”In this new editorial, researchers S.H. Tolmeijer, E. Boerrigter, N.P. Van Erp, and Niven Mehr…

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HER2-low and HER2-zero in Breast Cancer Between Prognosis, Prediction and Entity 2:41

2M ago2:41

2:41

BUFFALO, NY- July 16, 2024 – A new #editorial paper was #published in Oncotarget's Volume 15 on June 20, 2024, entitled, “HER2-low and HER2-zero in breast cancer between prognosis, prediction and entity.”In this new editorial, researchers Marcus Schmidt, Hans-Anton Lehr, and Katrin Almstedt from the University Medical Center of Johannes Gutenberg U…

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Comparison of FDG-PET/CT and CT for Treatment Evaluation of Patients With Unresectable Mesothelioma 4:12

2M ago4:12

4:12

BUFFALO, NY- July 15, 2024 – A new #research paper was #published in Oncotarget's Volume 15 on June 20, 2024, entitled, “Comparison of FDG-PET/CT and CT for evaluation of tumor response to nivolumab plus ipilimumab combination therapy and prognosis prediction in patients with unresectable malignant pleural mesothelioma.”Malignant pleural mesothelio…

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AI for Improved PET/CT Attenuation Correction in Prostate Cancer Imaging 5:51

2M ago5:51

5:51

Positron Emission Tomography (PET) combined with Computed Tomography (CT) is a powerful imaging modality used in oncology for diagnosis, staging, and treatment monitoring. However, one limitation of PET/CT is the need for accurate attenuation correction (AC) to account for tissue density variations. Traditionally, low-dose CT scans are used for AC,…

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Targeting ABC Transporters in PDAC – Past, Present, or Future? 3:00

2M ago3:00

3:00

BUFFALO, NY- July 10, 2024 – A new #editorial paper was #published in Oncotarget's Volume 15 on June 20, 2024, entitled, “Targeting ABC transporters in PDAC – past, present, or future?”In this new editorial, Cecilia Bergonzini, Elisa Giovannetti and Erik H.J. Danen from Leiden University discuss targeting ABC transporters in pancreatic ductal carci…

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Regorafenib Synergizes With TAS102 Against Multiple Gastrointestinal Cancers 3:25

2M ago3:25

3:25

BUFFALO, NY- July 8, 2024 – A new research paper was published in Oncotarget's Volume 15 on July 2, 2024, entitled, “Regorafenib synergizes with TAS102 against multiple gastrointestinal cancers and overcomes cancer stemness, trifluridine-induced angiogenesis, ERK1/2 and STAT3 signaling regardless of KRAS or BRAF mutational status.”Single-agent TAS1…

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Editorial: Genomics Has More to Reveal 2:33

2M ago2:33

2:33

BUFFALO, NY- July 2, 2024 – A new editorial paper was published in Oncotarget's Volume 15 on June 20, 2024, entitled, “Genomics has more to reveal.”In this new editorial, researchers Laurène Fenwarth and Nicolas Duployez from the University of Lille and CHU Lille discuss molecular and cytogenetic analyses that are now used to identify mutations and…

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Starving Cancer Cells to Enhance DNA Damage and Immunotherapy Response 2:55

3M ago2:55

2:55

BUFFALO, NY- June 26, 2024 – A new research perspective was published in Oncotarget's Volume 15 on June 20, 2024, entitled, “Starving cancer cells to enhance DNA damage and immunotherapy response.”Prostate cancer (PCa) poses significant challenges in treatment, particularly when it progresses to a metastatic, castrate-resistant state. Conventional …

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Leveraging Gold Nanostars for Precision Laser Interstitial Thermal Therapy 2:42

3M ago2:42

2:42

BUFFALO, NY- June 24, 2024 – A new editorial paper was published in Oncotarget's Volume 15 on June 14, 2024, entitled, “Leveraging gold nanostars for precision laser interstitial thermal therapy.”In this new editorial, researchers Aden P. Haskell-Mendoza, Ethan S. Srinivasan, Tuan Vo-Dinh and Peter E. Fecci from Duke University discuss laser inters…

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Impact of Dual Immunotherapies Before Surgery in HR+/HER2-negative Breast Cancer 8:47

3M ago8:47

8:47

Breast cancer immunotherapy has shown promise, but its clinical efficacy remains limited, especially for hormone receptor positive (HR+)/HER2-negative breast cancer. While immune checkpoint inhibitors combined with chemotherapy have benefitted some early-stage and metastatic triple-negative breast cancer patients, HR+/HER2-negative cases have seen …

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Assessment of CEA, CA-125, and CA19-9 as Adjuncts in Non-small Cell Lung Cancer Management 3:24

3M ago3:24

3:24

BUFFALO, NY- June 19, 2024 – A new research paper was published in Oncotarget's Volume 15 on June 13, 2024, entitled, “Assessment of serum tumor markers CEA, CA-125, and CA19-9 as adjuncts in non-small cell lung cancer management.”Conventional tumor markers may serve as adjuncts in non-small cell lung cancer (NSCLC) management. In this new study, r…

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When Does a Melanoma Metastasize? Implications for Management 2:18

3M ago2:18

2:18

BUFFALO, NY- June 18, 2024 – A new #research perspective was #published in Oncotarget's Volume 15 on June 13, 2024, entitled, “When does a melanoma metastasize? Implications for management.”In this new perspective, researchers John F. Thompson and Gabrielle J. Williams from The University of Sydney, Royal Prince Alfred Hospital, and the University …

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Episode 25: Dr. Shah & Dr. Babicky—Pathways to HPB Practice and Perspectives in Training 47:19

3M ago47:19

47:19

Today’s episode features Dr. Anushi Shah and Dr. Michele Babicky, discussing the hot topic of training paradigms in HPB. Dr. Babicky is a surgical oncologist and assistant professor of surgery at Providence Portland Medical Center. She is the program director of the HPB fellowship at her institution, with a passion for surgical education. Dr. Babic…

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Impact Journals Sponsors 2024 Ride for Roswell 3:59

3M ago3:59

3:59

BUFFALO, NY- June 11, 2024 – The Ride for Roswell is one of the nation’s largest cycling events—hosted by Roswell Park Comprehensive Cancer Center—to raise awareness and funds for cancer research and patient care. This charity bike ride, based out of Buffalo, New York, has brought people together for 28 years to celebrate cancer survivors, pay trib…

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Dr. Blagosklonny’s Strategy: From Osimertinib to Preemptive Combinations 8:07

3M ago8:07

8:07

In the relentless battle against non-small cell lung cancer (NSCLC) driven by epidermal growth factor receptor (EGFR) mutations, the development of resistance has long been a formidable obstacle. Historically, first- and second-generation EGFR tyrosine kinase inhibitors (TKIs) like gefitinib, erlotinib, afatinib, and dacomitinib have faced a signif…

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Synergistic Cytotoxicity of HDAC and PARP Inhibitors and Decitabine in Pancreatic Cancer Cells 3:38

3M ago3:38

3:38

BUFFALO, NY- June 5, 2024 – A new research paper was published in Oncotarget's Volume 15 on June 3, 2024, entitled, “Synergistic cytotoxicity of histone deacetylase and poly-ADP ribose polymerase inhibitors and decitabine in pancreatic cancer cells: Implications for novel therapy.”Histone deacetylase inhibitors (HDACi) can modulate the acetylation …

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BTK Inhibitor-related Cardiotoxicity: Quest for Predictive Biomarkers, Improved Risk Stratification 2:29

3M ago2:29

2:29

BUFFALO, NY- June 4, 2024 – A new research perspective was published in Oncotarget's Volume 15 on June 3, 2024, entitled, “Bruton’s tyrosine kinase inhibitor-related cardiotoxicity: The quest for predictive biomarkers and improved risk stratification.”In this new perspective, researchers Jai N. Patel, Jai Singh, and Nilanjan Ghosh from Atrium Healt…

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Behind the Study: Anticancer Potential of CLK Kinase Inhibitors 1C8 and GPS167 6:46

3M ago6:46

6:46

Dr. Benoit Chabot from Université de Sherbrooke in Quebec, CA, discusses a research paper he co-authored that was published by Oncotarget in Volume 15, entitled, “The anticancer potential of the CLK kinases inhibitors 1C8 and GPS167 revealed by their impact on the epithelial-mesenchymal transition and the antiviral immune response.”DOI - https://do…

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The Importance of Integrated Therapies on Cancer: Silibinin, an Old and New Molecule 3:15

3M ago3:15

3:15

BUFFALO, NY- May 28, 2024 – A new review paper was published in Oncotarget's Volume 15 on May 23, 2024, entitled, “The importance of integrated therapies on cancer: Silibinin, an old and new molecule.”In this new review, researchers Elisa Roca, Giuseppe Colloca, Fiorella Lombardo, Andrea Bellieni, Alessandra Cucinella, Giorgio Madonia, Licia Martin…

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Combating Doxorubicin-Resistant Acute Myeloid Leukemia 10:39

4M ago10:39

10:39

Upon diagnosing acute myeloid leukemia (AML), the initial step involves assessing a patient’s eligibility for intensive chemotherapy. The standard treatment protocol for newly diagnosed AML encompasses intensive chemotherapy to achieve complete remission, followed by post-remission therapy, which may include additional chemotherapy and/or stem cell…

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GZ17-6.02 Kills Uveal Melanoma Cells 3:53

4M ago3:53

3:53

BUFFALO, NY- May 22, 2024 – A new research paper was published in Oncotarget's Volume 15 on May 17, 2024, entitled, “GZ17-6.02 kills PDX isolates of uveal melanoma.”In this new study, researchers Laurence Booth, Jane L. Roberts, Ivan Spasojevic, Kaitlyn C. Baker, Andrew Poklepovic, Cameron West, John M. Kirkwood, and Paul Dent from Virginia Commonw…

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Anticancer Potential of CLK Kinase Inhibitors 1C8 and GPS167 via EMT and Antiviral Immune Response 3:19

4M ago3:19

3:19

BUFFALO, NY- May 20, 2024 – A new research paper was published in Oncotarget's Volume 15 on May 16, 2024, entitled, “The anticancer potential of the CLK kinases inhibitors 1C8 and GPS167 revealed by their impact on the epithelial-mesenchymal transition and the antiviral immune response.”The diheteroarylamide-based compound 1C8 and the aminothiazole…

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Expression of Cyclin D1 in Penile Cancer 3:36

4M ago3:36

3:36

BUFFALO, NY- May 15, 2024 – A new #research paper was #published in Oncotarget's Volume 15 on May 14, 2024, entitled, “Cyclin D1 expression in penile cancer.”In this new study, researchers Wesliany Everton Duarte, Jaqueline Diniz Pinho, Syomara Pereira da Costa Melo, Denner Rodrigo Diniz Duarte, Juliana Martins da Guia Ribeiro do Carmo, André Salim…

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Oncotarget at SSP 46th Annual Meeting 1:30

4M ago1:30

1:30

BUFFALO, NY- May 13, 2024 – BUFFALO, NY- May 13, 2024 – Impact Journals publishes scholarly journals in the biomedical sciences, with a focus on all areas of cancer and aging research. Oncotarget is one of the most prominent journals published by Impact Journals.Impact Journals is proud to participate at the Society for Scholarly Publishing (SSP) 4…

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SARS-CoV-2 Spike Protein Disrupts p53 Tumor Suppressor Pathway 9:24

4M ago9:24

9:24

The profound impact of the COVID-19 pandemic, caused by the SARS-CoV-2 virus, has been felt across various domains, including the realm of cancer research and treatment. As scientists delve deeper into the intricate mechanisms of this viral pathogen, intriguing revelations have emerged regarding its potential influence on cellular processes pivotal…

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Deep Learning-based Whole-body Prostate-specific Membrane Antigen PET/CT Attenuation Correction 3:42

4M ago3:42

3:42

BUFFALO, NY- May 8, 2024 – A new research paper was published in Oncotarget's Volume 15 on May 7, 2024, entitled, “Deep learning-based whole-body PSMA PET/CT attenuation correction utilizing Pix-2-Pix GAN.”The sequential PET/CT studies oncology patients can undergo during their treatment follow-up course is limited by radiation dosage. In this new …

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