Upgrading The Physiological Relevance Of Human Brain Organoids Stem Cell Channel (Audio) podcast

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Upgrading the Physiological Relevance of Human Brain Organoids

3M ago 53:09

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Indhold leveret af UCTV. Alt podcastindhold inklusive episoder, grafik og podcastbeskrivelser uploades og leveres direkte af UCTV eller deres podcastplatformspartner. Hvis du mener, at nogen bruger dit ophavsretligt beskyttede værk uden din tilladelse, kan du følge processen beskrevet her https://da.player.fm/legal.

Giorgia Quadrato, Ph.D., explores cerebral organoids as models for neural development and disease research. Using live calcium imaging, Quadrato observes increased neuronal coordination attributed to inhibitory neurons, validated through pharmacological and genetic methods. Quadrato contrasts their organoid generation protocol with previous methods, emphasizing complex patterning, long-term cultures, and co-culture with mouse brain cells for improved physiological relevance. Microfluidics are utilized for enhanced oxygenation and physiological conditions. Future efforts focus on incorporating microglial cells for synaptic pruning studies and overcoming challenges in cryopreservation. Overall, the research aims to advance understanding of neural mechanisms and diseases, enhancing organoid fidelity for biomedical applications. Series: "Women in Science" [Health and Medicine] [Science] [Show ID: 39456]

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100 episoder

Artwork

Upgrading the Physiological Relevance of Human Brain Organoids

Stem Cell Channel (Audio)

published 3M ago

Del

MP3•Episode hjem

Indhold leveret af UCTV. Alt podcastindhold inklusive episoder, grafik og podcastbeskrivelser uploades og leveres direkte af UCTV eller deres podcastplatformspartner. Hvis du mener, at nogen bruger dit ophavsretligt beskyttede værk uden din tilladelse, kan du følge processen beskrevet her https://da.player.fm/legal.

Giorgia Quadrato, Ph.D., explores cerebral organoids as models for neural development and disease research. Using live calcium imaging, Quadrato observes increased neuronal coordination attributed to inhibitory neurons, validated through pharmacological and genetic methods. Quadrato contrasts their organoid generation protocol with previous methods, emphasizing complex patterning, long-term cultures, and co-culture with mouse brain cells for improved physiological relevance. Microfluidics are utilized for enhanced oxygenation and physiological conditions. Future efforts focus on incorporating microglial cells for synaptic pruning studies and overcoming challenges in cryopreservation. Overall, the research aims to advance understanding of neural mechanisms and diseases, enhancing organoid fidelity for biomedical applications. Series: "Women in Science" [Health and Medicine] [Science] [Show ID: 39456]

… continue reading

100 episoder

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