Breakthroughs is a podcast about groundbreaking research and the scientists leading these discoveries at Northwestern University Feinberg School of Medicine. We are driven by our mission to transform the practice of medicine and profoundly impact human health beyond the individual patient. We believe better answers only come from discovery.
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Applying to medical school can be a very complex and confusing process! All Access: Med School Admissions by Christian Essman, Senior Director of Admissions & Financial Aid at Case Western Reserve University School of Medicine in Cleveland, Ohio, brings listeners into informative and entertaining conversations between admissions colleagues from medical schools across the US. Christian and his guests try to bring transparency to the medical school application process and help prospective appl ...
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Host: Samir Kakodkar, MD - specialist in Crohn's disease and ulcerative colitis Medical School: Northwestern Feinberg School of Medicine Internal Medicine Residency: Rush University Medical Center Fellowship in Gastroenterology and Hepatology: Advocate Lutheran General Hospital Advanced Fellowship in Inflammatory Bowel Disease (Crohn's and Colitis): Northwestern Memorial Hospital Practice Location 7900 N Milwaukee Ave Suite 19, Niles, IL 60714 For appointments: 847-318-9595 Contact: samir3@g ...
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Episode 74: Project Horseshoe Farm with Founder, Dr. John Dorsey
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In this episode, we take you to Greensboro, Alabama, home of the Horseshoe Farm Community Health Project. Imagine the peaceful charm of rural Alabama as we explore how this incredible initiative, which also serves as a gap year option for premedical students, provides mentorship, healthcare support, and a strong sense of belonging to the underserve…
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Episode 73: Special Medical Masters Program of Brown University Alpert Medical School
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In this episode, we're exploring gap year options with a focus on the Master of Science in Medical Sciences at The Warren Alpert Medical School of Brown University. I chat with Dr. Deborah Gutman, Director of Pre-health Advising at for the program, about the differences between post-bac and masters programs and how they impact GPA calculations for …
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How to Measure Biological Age with John Wilkins, MD
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A team of Northwestern Medicine scientists are conducting a new longitudinal cross-sectional study to investigate why some people see to age faster than others. In this episode, John Wilkins, MD, associate director of the Human Longevity Laboratory at the Potocsnak Longevity Institute, shares details of the study, which will eventually include a va…
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Episode 72: Updates & Applicant Tips with Christian Essman
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It's been awhile! In this episode, Christian Essman brings you the latest updates and some tips for those currently navigating the application process. If you find this podcast to be a helpful resource, RATE, REVIEW, & SUBSCRIBE please! It helps others find it! Send me your recommendations for future medical schools that you'd like to hear featured…
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A Compelling New Lupus Discovery with Jaehyuk Choi, MD, PhD
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Northwestern Medicine physician-scientist Jaehyuk Choi, MD, PhD joins the show again to discuss another breakthrough. This time for lupus, a chronic autoimmune condition affecting 300,000 Americans that can cause inflammation in many body parts, including joints, skin, kidneys, blood cells, brain, heart and lungs. Findings by Choi and his lab membe…
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Uncovering Insights into Cancer and Alzheimer's with Marcus Peter, PhD
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For decades, Marcus Peter, PhD, has drilled into an area of research focused on cell death and the roles of toxic and protective short RNAs, with the goal of developing a novel form of cancer treatment. Now, this same line of research has led Peter’s team to uncover new insights into the cause of Alzheimer's disease. In this episode, Peter explains…
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The Evolution of Digital Pathology with Lee Cooper, PhD
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New advances in digital pathology are revolutionizing the analysis of disease, paving the way for greater accuracy and efficiency when it comes to diagnostics, predicting outcomes and treatment. In this episode, Lee Cooper, PhD, discusses the future of digital and computational pathology and his research on machine learning and pathology, including…
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Driving Innovations in Biostatistics with Denise Scholtens, PhD
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Northwestern University Feinberg School of Medicine is home to a team of premier faculty and staff biostatisticians who are a driving force of data analytic innovation and excellence. In this episode, Denise Scholtens, PhD, a leader in biostatistics at Feinberg, discusses the growing importance of the field of biostatistics and how she leverages he…
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Leading Pediatric Obesity Research with Justin Ryder, PhD
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Northwestern Medicine scientists are at the forefront of research investigating the most effective ways of treating obesity in children and teens and improving their access to care. In this episode, Justin Ryder, PhD, a clinical and translational obesity scientist at Feinberg, talks about the use of new GLP-1–based medications for childhood obesity…
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Discovering New ALS Therapeutic Avenues with Evangelos Kiskinis, PhD
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An estimated 32,000 Americans are currently living with ALS, or amyotrophic lateral sclerosis, a progressive neurodegenerative disease that attacks motor neurons in the brain and spinal cord. Northwestern investigators have uncovered novel cellular mechanisms involved in two types of genetic ALS that might lead to future targeted therapies. Evangel…
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Pursuing Deeper Understanding of Inflammation with Murali Prakriya, PhD
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Inflammation is a common feature of many diseases and Northwestern Medicine investigators have identified how a calcium channel contributes to inflammation in the brain and lungs. This could aid in finding new types of therapeutics for inflammation-related diseases and conditions. In this episode, Murali Prakriya, PhD, discusses the evolution of th…
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Partnering with Libraries to Address Teen Mental Health with Ashley Knapp, PhD, and Robert Simmons, MA
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Teens are reporting struggles with their mental health at unprecedented rates, but resources to help these young people deal with anxiety or depression can be difficult to access. In this episode, Ashley Knapp, PhD, assistant professor of Psychiatry and Behavioral Sciences, and Robert Simmons, MA, director of social services and public safety at Oa…
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Engineering Bacteria to Monitor and Treat Disease with Arthur Prindle, PhD
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Thanks to advancements in synthetic biology, scientists are now engineering bacterial communities with the goal of using these cells to monitor and treat diseases. In this episode, Arthur Prindle, PhD, explains how his lab is reprogramming bacteria that may be used in the future to detect disease and deliver therapeutics for many different conditio…
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Strengthening T-Cell Therapy for Solid Tumor Cancers with Jaehyuk Choi, MD, PhD
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A new study published in the journal Nature details breakthrough T-cell immunotherapy research from Northwestern Medicine. In this episode, Jaehyuk Choi, MD, PhD, senior author of the paper, explains how a gene mutation found in T-cells of patients with lymphoma could hold the key to a potent cancer-fighting immunotherapy for solid tumor cancers, w…
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Episode 71: University of Michigan Medical School Updates
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In this enlightening episode, I sit down with the recently appointed, dynamic Assistant Dean for Admissions at the University of Michigan Medical School, Dr. Deborah Berman. Dr. Berman offers an in-depth look into the significant curricular updates, wellness initiatives, and the evolving admissions landscape at one of the premier medical schools in…
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Episode 70: AAMC Prospective Applicant Resources
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Welcome to this special episode where we delve into the treasure trove of resources available for prospective medical school applicants. Today, we're joined by Tami Levin, MA, the Director of Premed and Applicant Resources at the AAMC, and Laura Fletcher, PhD, a senior research analyst in the Admissions & Selection Research and Development team at …
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New Insights into Dopamine with Raj Awatramani, PhD, and Daniel Dombeck, PhD
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When most of us think about dopamine, we think about reward signals. But new research from Northwestern Medicine, published in Nature Neuroscience, has found a genetic subtype of dopamine neurons that do not respond to rewards at all, and instead, fire when the body moves. Rajeshwar Awatramani, PhD, and Daniel Dombeck, PhD led this work. In this ep…
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The Evolution of the NIH Toolbox with Richard Gershon, PhD
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As the primary investigator of The NIH Toolbox®, Richard Gershon, PhD, has led a team of hundreds of scientists to develop and evolve state-of-the-art digital assessments of cognition, motor, sensation and emotion which has been used by clinicians, investigators and academics for nearly two decades. In this episode, Gershon explains how the third v…
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How Mitochondria Inform Disease Discoveries with Navdeep Chandel, PhD
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Mitochondria are widely known as cellular “powerhouses” for their role in producing energy for cells. But pioneering research from Northwestern Medicine investigators over the last 20 years has proven mitochondria are also major players in lung disease, cancer, brain disease and immune-related diseases. Navdeep Chandel, PhD, a 2023 recipient of the…
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Advancing Transplant Science with Daniela Ladner, MD, MPH
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Northwestern Medicine is dedicated to improving outcomes for patients who are in need of organ transplants. Daniela Ladner, MD, MPH, is leading research that sheds light on the barriers to transplantation as the founding director of the Northwestern University Transplant Outcomes Research Collaborative (NUTORC). She discusses the groundbreaking res…
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Episode 69: Northwestern University Feinberg School of Medicine
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Dr. Roopal Kundu, Associate Dean for Admissions, highlights the unique curricular features and educational philosophy at Northwestern University Feinberg School of Medicine, shedding light on their innovative approaches to medical education. From fostering curiosity and inquiry to promoting equity through group and problem-based learning, Dr. Kundu…
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How Drinking Alcohol Impacts Aging with Lifang Hou, MD, PhD
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Both long-term alcohol consumption and binge drinking can speed up biological aging, according to a Northwestern Medicine study published in the journal Aging. Lifang Hou, MD, PhD, chief of Cancer Epidemiology and Prevention in the Department of Preventive Medicine led the study and discusses the link between genetics and lifestyle in the context o…
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How AI Can Improve Healthcare Delivery with Mozzi Etemadi, MD, PhD
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Mozziyar “Mozzi” Etemadi, MD, PhD, is supporting the transformation of healthcare delivery and patient care at Northwestern Medicine by bringing engineers into direct contact with clinical providers. In this episode, he talks about the explosion of artificial intelligence in healthcare in recent years and how Northwestern Medicine is using this tec…
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Predicting Which Cancer Cells May Become Drug-Resistant with Yogesh Goyal, PhD
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Treating cancer has become increasingly difficult as cells develop resistance. Northwestern investigators have sought to address this issue on the cellular level through the development of a novel FateMap tool, used to predict the future behavior of cancer cells before they are exposed to cancer-fighting drugs. In this episode, Yogesh Goyal, PhD, d…
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New Institute Advances Lung Disease Research and Clinical Care with Scott Budinger, MD
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The launch of the Simpson Querrey Lung Institute for Translational Science (SQLIFTS) at Northwestern University Feinberg School of Medicine aims to expedite the discovery and implementation of innovative lung disease treatments through a patient-centered approach. In this episode, Scott Budinger, MD, the new executive director of the institute, dis…
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Understanding Genetic Factors in Parkinson's Disease with Steven Lubbe, PhD
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The global prevalence of Parkinson's disease has doubled in the past 25 years. While research into this extremely diverse neurodegenerative disorder is very active, there is much left to be uncovered about the underlying cause of the disease. Recently, Northwestern Medicine investigators have discovered novel genetic factors contributing to the ris…
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Bonus Episode: Listener Event Announcement!
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Join us for an exclusive Zoom event featuring Christian Essman, the host of "All Access: Med School Admissions." Are you an aspiring medical student with burning questions about the admissions process? Look no further! This is your chance to spend an engaging evening with Christian Essman and have all your inquiries answered. During this virtual ga…
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Episode 67: UMass Chan Medical School
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I had the pleasure of speaking with Dr. Tracy Kedian, the Associate Dean for Admissions, at the UMass Chan Medical School in Worcester, MA. Dr. Kedian sheds light on the unique aspects of UMass Chan's curriculum, known as VISTA. This innovative curriculum fosters curiosity, inquiry, and equity through group and problem-based learning, along with ex…
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Why Late-Night Eating is Linked to Weight Gain and Diabetes with Joseph Bass, MD, PhD
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19:46
Disrupting our internal clocks can lead to diseases such as obesity and diabetes. Scientists at Northwestern have uncovered the mechanism behind why late-night eating is linked to weight gain and diabetes. Joseph Bass, MD, PhD, led the study published in the journal Science. He shares the results and details the two decades of work leading to this …
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Rewind: A Promising Obesity Drug with Robert Kushner, MD
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This episode was released in February 2021, and is being re-shared to offer the research behind the popular weight loss drugs Ozempic and Wegovy. Northwestern's Robert Kushner, MD, discusses the drug semaglutide, typically prescribed for treatment of Type 2 diabetes and the results of the phase 3 clinical trial as a treatment for obesity with very …
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Improving Exercise Habits for Breast Cancer Survivors with Siobhan Phillips, PhD, MPH
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There's strong evidence that physical activity can play an important role in the health and lifespan of cancer survivors. Siobhan Phillips, PhD, MPH, leads the Exercise and Health Lab at Feinberg, which designs, tests, implements and disseminates physical activity interventions to support cancer survivors. In this episode, Phillips details interven…
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Advancing Skin Cell Biology with Kathleen Green, PhD
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22:33
Skin diseases from psoriasis to melanoma affect as many as one in three Americans at any given time. Kathleen Green, PhD, has greatly advanced basic molecular research related to skin diseases. She discusses recent discoveries in her lab that could lead to future therapeutic targets.Af Northwestern University
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Rewind: How to Stop Antibiotic Misuse with Jeffrey Linder, MD, MPH
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Physicians are notorious for prescribing antibiotics as a "quick fix" when they aren't necessary. There are many reasons why, and Jeffrey Linder, MD, MPH, dives into those and discusses effective ways to reduce the number of inappropriate prescriptions by working with physicians. Originally released in fall 2018, this episode is still timely as the…
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Episode 66: U. of Texas - San Antonio Long School of Medicine
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Dr. Judianne Kellaway, the Associate Dean for Admissions & Outreach, at the Joe R. & Teresa Lozano Long School of Medicine at University of Texas Health San Antonio joins me for a entertaining and wonderfully informative conversation. Dr. Kellaway takes us through the highlights and unique aspects of their CIRCLE curriculum including, professional …
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Episode 65: Rutgers University Robert Wood Johnson Medical School
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The Assistant Dean of Medical Education and Admissions, Dr. Liesel Copeland, joins me to discuss the curricular highlights and admissions process at Rutgers University Robert Wood Johnson Medical School. In 2021, the medical school launched the 5 C’s Curriculum: Curiosity, Critical Thinking, Clinical Skills, Competence and Compassion which we talk …
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Can ChatGPT Support Biomedical Research? with Catherine Gao, MD and Yuan Luo, PhD
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Northwestern scientists Yuan Luo, PhD, and Catherine Gao, MD, discuss a study they conducted using the artificial intelligence chatbot, ChatGPT. The results showcase the online tool's ability to produce convincing medical research abstracts. They also discuss the tool’s potential to help with writing-intensive tasks in healthcare and medical resear…
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Episode 64: Catching Up with Dr. Lina Mehta on Admissions-related Topics
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I sat down with Dr. Lina Mehta, Associate Dean for Admissions at the CWRU School of Medicine to discuss some admissions-related topics. We reflected on the previous application cycle, current topics is admissions, and looking ahead to the next cycle. We think you'll find this episode to be informative and, hopefully, entertaining! If you find this …
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How the Brain Regulates Aggressive Behavior with Ann Kennedy, PhD
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A theoretical neuroscientist, Ann Kennedy, PhD, is investigating neural computation and the structure of behavior. In this episode, she talks about her recent research in the area of aggression and how it's regulated in the brains of animals. She was recently named the winner of the 2022 Eppendorf and Science Prize for Neurobiology.…
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Rewind: Can Exercise Slow Parkinson's Disease Progression? with Daniel Corcos, PhD
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Parkinson's disease is the second most prevalent neurodegenerative disease, and nearly one million people have Parkinson's disease in the U.S. A $30 million dollar, phase 3 clinical trial at Northwestern is investigating whether exercise can slow Parkinson's disease progression. Daniel Corcos, PhD, a professor of Physical Therapy and Human Movement…
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A New Focus on Implementation Science with Sara Becker, PhD, and Rinad Beidas, PhD
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To have the greatest impact on human health, biomedical research findings and evidence-based practices need to be implemented into routine healthcare. What is implementation science, and how can we ensure research successfully makes an impact? Rinad Beidas, PhD, and Sara Becker, PhD, discuss the field and its future as a research priority at Northw…
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Rewind: Why are Food Allergies on the Rise? with Ruchi Gupta, MD, MPH
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There’s been an uptick in childhood food allergies in recent years, and new evidence from Northwestern shows they’re also becoming more common in adults. Many of the reactions to these allergies are life-threatening. Why is this increase happening, and how can we keep people affected by food allergy safe? Ruchi Gupta, MD, MPH, is trying to answer t…
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Episode 63: University of Tennessee Health Science Center College of Medicine
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Join me for an informative conversation with the Assistant Dean of Admissions, Dr. Dustin Fulton, from UTHSC. As one of two public allopathic medical schools in the State of Tennessee, it is a popular destination for many premed students. The College has a strong commitment to training physicians who plan to go into primary care practice. Throughou…
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The Science Behind Culinary Medicine with Melinda Ring, MD
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17:03
A Northwestern Medicine course called Cooking Up Health is giving medical students, trainees and health professionals the opportunity to learn culinary medicine and food-as-medicine science concepts. Melinda Ring, MD, created the course and explains how it can improve the health of patients and train more nutrition-aware physicians.…
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Identifying How Genes Function to Better Understand Cancer with Mazhar Adli, PhD
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Understanding how genes function is a vital part of understanding how to better treat cancer. Research led by Mazhar Adli, PhD, is grounded in the development of a systematic approach to identify the function of each gene in the human body. His team aims to discover novel therapeutic drug combinations to prevent cancer development and chemotherapy …
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The Long-term Impact of Bariatric Surgery in Adolescents with Thomas Inge, MD, PhD
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Bariatric surgery is proving to be an effective tool to help teenagers with severe obesity lose weight and reverse the progression of weight-related conditions, according to findings from the Teen Longitudinal Assessment of Bariatric Surgery study (Teen-LABS). Thomas Inge, MD, PhD, principal investigator of Teen-LABS, shares results of the study, w…
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Episode 62: 2022-23 Mid-Cycle Check-In
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24:24
Checking in midway through the 2022-2023 application cycle with updates and tips for current applicants and advice for prospective applicants. If you find this podcast to be a helpful resource, RATE, REVIEW, & SUBSCRIBE please! It helps others find it! Send me your recommendations for future medical schools that you'd like to hear featured! Send it…
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The Role of Dopamine in Habit Formation and Compulsive Behavior with Talia Lerner, PhD
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23:03
How are habits – both good and bad – formed in the brain, and what role do habits play in diseases of the brain? These are some of the questions neuroscientist, Talia Lerner, PhD, is investigating in her lab. Her recent study, published in Cell Reports, may change the overall understanding of how habits are formed and could be broken.…
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Understanding the Immune System with Stephanie Eisenbarth, MD, PhD
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20:51
Uniting scientists and harnessing the power of the immune system to fight disease is at the heart of the new Center for Human Immunobiology at Northwestern University Feinberg School of Medicine. Stephanie Eisenbarth, MD, PhD is leading the new center, she is also the new chief of Allergy and Immunology in the Department of Medicine. She discusses …
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Improving Health Outcomes Through Big Data with Theresa Walunas, PhD
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In recent years, Feinberg has launched several initiatives to augment human expertise with computational methods and advance the science of human health. Theresa Walunas, PhD, explains how she is using big data from electronic medical records in a variety of projects at Feinberg, from improving quality of care to identifying patients who could deve…
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Episode 61: Sharing A New Podcast & MCAT Resources
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23:48
The podcasting community is a small, supportive community and when I heard of this new podcast from the University of Chicago Pritzker School of Medicine, I knew I had to share it with you, my premed listeners. It is called, “The Clinical Excellence Podcast” and can be helpful and provide insight for our premed listeners to hear how physicians navi…
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