Status Epilepticus & the EcLiPSE Trial

Take Aurally

Status epilepticus is the most common paediatric neurological emergency in the UK and the second most common reason for unplanned PICU admission in the UK. Dr Colin Gilhooley defines status epilepticus before discussing the EcLiPSE trial: Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial This was a UK wide trial across 30 Emergency Departments (including our own in Nottingham) comparing Phenytoin as the standard 2nd line treatment to Levetiracetam as an alternative with a smaller side effect profile. The result was (spoilers): NO SIGNIFICANT DIFFERENCE. Colin take us through the potential consequences of this, how this might change practice as well as what it was like to be involved in the trial and what deferred consent might mean in the future. You can find the blog for this episode at https://www.takeaurally.com/paediatric-emergency-medicine/2019/7/3/paediatric-status-epilepticus-amp-the-eclipse-trial As ever you can subscribe to Take Aurally through Apple Podcasts and Soundcloud AND we're also on Spotify: open.spotify.com/user/hk2tt55xd97pcz4xoj43nydyy Remember to follow us and NUH DREEAM on Facebook and Twitter We're now also on Instagram where you can find our whole collection of Take Visually infographics: www.instagram.com/takeaurally/